Van Dyke first gained recognition on radio and Broadway, then he became known for his role as Rob Petrie on the CBS television sitcom The Dick Van Dyke Show, which ran from 1961 to 1966. He also gained significant popularity for roles in the musical films Bye Bye Birdie (1963), Mary Poppins (1964), and Chitty Chitty Bang Bang (1968). His other prominent film appearances include roles in The Comic (1969), Dick Tracy (1990), Curious George (2006), Night at the Museum (2006), Night at the Museum: Secret of the Tomb (2014), and Mary Poppins Returns (2018). Other prominent TV roles include the leads in The New Dick Van Dyke Show (1971–74), Diagnosis: Murder (1993–2001), and Murder 101 (2006–08) which both co-starred his son Barry.
Van Dyke is the recipient of five Primetime Emmys, a Tony, and a Grammy Award, and was inducted into the Television Hall of Fame in 1995. He received the Screen Actors Guild’s highest honor, the SAG Life Achievement Award, in 2013. He has a star on the Hollywood Walk of Fame at 7021 Hollywood Boulevard and has also been recognized as a Disney Legend.