Bracco moved to France in 1974, where she became a fashion model for Jean-Paul Gaultier. She lived there for about a decade. While still modeling, Bracco was approached by Marc Camoletti, who offered her a major role in the film adaptation of one of his plays, Duos sur canapé (1979). Bracco did not imagine that she could be an actress, and initially refused. She eventually made the film, but found the experience “boring” and her performance “terrible.” Nevertheless, she played supporting roles in two other French films “for the money.” After one of her friends suggested that she might enjoy acting if she took some training, she took seminars with John Strasberg. Although she loved the lessons, she was still unsure of her talents. During the 1980s, she also worked as a disc jockey for Radio Luxembourg. Also, she appeared as Paul Guilfoyle’s hostage in the first season Crime Story episode, “Hide and Go Thief”. Her sister Elizabeth played a hostage in the series pilot. Eventually, Italian director and novelist Lina Wertmüller gave Bracco a small part in the film Camorra. “She dressed me up like an Italian woman of no means. A street woman clad in disheveled clothes, hair unkempt and all that, and threw me on the set. She was so creative. I mean, Lina accentuated my eyes with dark make-up, the way Sophia Loren used to appear in those epic roles in the ’60s. And talk about talent. She’s so bright and perceptive. I mean, she’s just fantastic. And yes, I learned a lot from her. She’s a master of her profession, and I’ve been blessed not only with her, but also with so many masters,” recounted Bracco to Daniel Simone during a 2007 interview. The experience inspired Bracco to pursue acting. Her other films include Someone to Watch Over Me, Switch, Riding in Cars with Boys, The Basketball Diaries, Medicine Man, Radio Flyer, and Hackers. Bracco was one of many actresses who were considered for the role of Catwoman/Selina Kyle in Tim Burton’s film Batman Returns but declined the role. Bracco received her big career break when she was offered the role of mobster wife Karen Hill in Goodfellas, which earned her an Academy Award nomination for Best Supporting Actress and a Golden Globe nomination for Best Supporting Actress – Motion Picture. She won the Los Angeles Film Critics Association Award for Best Supporting Actress and the Chicago Film Critics Association Award for Best Supporting Actress. During the audition process for The Sopranos, David Chase wanted Bracco to read for the lead female role of Carmela Soprano. However, Bracco had read the script and was drawn to the part of psychiatrist Jennifer Melfi. Bracco felt so strongly about her ability and desire to play the part that she arranged a meeting with Chase and talked him into letting her have a chance as Melfi. It netted her three consecutive nominations for Outstanding Lead Actress in a Drama Series at the Emmy Awards in 1999, 2000, and 2001, and at the Golden Globe awards for Best TV Actress in a Drama in 2000, 2001, and 2002. She lost out at the Emmys in 1999 and 2001, and at the Golden Globes in 2000 to her co-star Edie Falco. She was nominated again at the 2007 Emmy Awards for Outstanding Supporting Actress in a Drama Series, and thus was pitted against her The Sopranos co-star Aida Turturro for the award. Bracco is the owner of Bracco Wines, in association with Straight-Up Brands LLC. Her line of wines was featured on the Season 1 finale of Bravo’s show Top Chef in 2006. She appeared as a guest judge for the show’s two-episode finale and as a special judge on Top Chef: All Stars, in the episode titled “An Offer They Can’t Refuse”, which featured Italian cuisine. Bracco also appeared on a season 6 episode of Throwdown! with Bobby Flay, as a guest judge for the ravioli throwdown. Beginning in 2016, Bracco had a recurring role as Toni on the Showtime comedy series Dice. From 2017 to 2018, she had a five-episode recurring role as Mayor Margaret Dutton in the CBS police drama series Blue Bloods. In 2020, Bracco starred in the HGTV documentary television series shot in Sambuca di Sicilia, My Big Italian Adventure, and chronicling her 200-year-old, €1 house renovation at Via Guglielmo Marconi.